Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biomaterials. 2013 Jan;34(4):1281-8. doi: 10.1016/j.biomaterials.2012.10.025. Epub 2012 Nov 9.
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
我们开发了一种药物传递系统,可通过单次给药实现经鼓膜的抗生素的长时间传递。通过化学渗透增强剂(布比卡因、柠檬烯、十二烷基硫酸钠)增加完整鼓膜(TM)对环丙沙星的通透性;这也可以通过包含在水凝胶(泊洛沙姆 407)中的渗透增强剂看到,以将制剂保持在 TM 处。渗透增强剂-水凝胶制剂对体内听阈和组织反应的影响最小。渗透增强剂-水凝胶制剂具有用于经鼓膜给予环丙沙星的潜力,可用于治疗急性中耳炎(AOM)和其他中耳疾病。