Alliët P, Van Lierde S, Bruylants B, Van Laer P, Devlieger H, Eggermont E
Afd. Kindergeneeskunde, Dienst Neonatologie, Universitair Ziekenhuis Gasthuisberg, K.U. Leuven.
Tijdschr Kindergeneeskd. 1992 Feb;60(1):18-21.
During the period november 1988-december 1989 eight cases of early onset neonatal Listeria monocytogenes infection were registered in the 'Neonatal Intensive Care Unit' of the University Hospital in Leuven (Belgium). Before bacteriological proof was available, diagnosis could be made in 7 cases, based on a characteristic clinical picture: a maternal flu-like syndrome leading to preterm labour with intact membranes, meconium stained amniotic fluid, perinatal asphyxia and respiratory distress of the neonate. In 5 infants a maculopapulovesicular skin eruption was present. Laboratory findings were non-specific. An interesting finding was the predominance of monocytes in the endotracheal aspirate of infected infants. In 5 out of 8 patients meningitis and intraventricular hemorrhage were present; two of them died, three developed severe neurological sequelae.
1988年11月至1989年12月期间，比利时鲁汶大学医院的“新生儿重症监护病房”记录了8例早发型新生儿单核细胞增生李斯特菌感染病例。在获得细菌学证据之前，7例病例可根据典型的临床表现作出诊断：母亲出现类似流感的综合征，导致胎膜完整的早产、羊水胎粪污染、围产期窒息和新生儿呼吸窘迫。5名婴儿出现斑丘疹水疱性皮肤疹。实验室检查结果无特异性。一个有趣的发现是感染婴儿气管内吸出物中单核细胞占优势。8例患者中有5例出现脑膜炎和脑室内出血；其中2例死亡，3例出现严重的神经后遗症。
