Hsieh Wu-Shiun, Tsai Li-Yi, Jeng Suh-Fang, Hsu Chyong-Hsin, Lin Hong-Chih, Hsueh Po-Ren, Chen Chien-Yi, Chou Hung-Chieh, Tsao Po-Nien, Yang Peng-Hong
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Int J Infect Dis. 2009 Mar;13(2):193-5. doi: 10.1016/j.ijid.2008.06.006. Epub 2008 Sep 3.
Listeria monocytogenes is an important pathogen in neonates in Western countries, with a fatality rate of 20-30%. There is limited information on neonatal listeriosis in Eastern countries. The purpose of this study was to delineate the occurrence and clinical picture of neonatal listeriosis in Taiwan.
A questionnaire-based survey of all of the 17 medical centers in Taiwan was performed, and a literature review of neonatal listeriosis as reported in Taiwan from 1990 to 2007 was made.
A total of 14 cases (10 male, four female) of neonatal listeriosis were identified, including 11 found from the survey of four medical centers and another three collected from the literature review. Three were found to have occurred prior to 2000 and 11 were found to have occurred after 2000. The age of onset was less than 3 days in all cases. L. monocytogenes was identified from blood in 13, cerebrospinal fluid in four, and gastric aspirate in two. Half of the cases (7/14) had involvement of the central nervous system with pleocytosis and hypoglycorrhachia in cerebrospinal fluid, and three of them even developed hydrocephalus. The mortality rate was 29%.
Our findings suggest that listeriosis may emerge as an important health threat among newborn infants in Taiwan.
在西方国家，单核细胞增生李斯特菌是新生儿的一种重要病原体，病死率为20% - 30%。关于东方国家新生儿李斯特菌病的信息有限。本研究的目的是描述台湾新生儿李斯特菌病的发病情况及临床表现。
对台湾所有17家医学中心进行了问卷调查，并对1990年至2007年台湾报道的新生儿李斯特菌病进行了文献回顾。
共确诊14例新生儿李斯特菌病病例（男10例，女4例），其中11例来自4家医学中心的调查，另外3例来自文献回顾。3例发生在2000年之前，11例发生在2000年之后。所有病例发病年龄均小于3天。13例血液中检出单核细胞增生李斯特菌，4例脑脊液中检出，2例胃吸出物中检出。半数病例（7/14）累及中枢神经系统，脑脊液中出现细胞增多和低糖血症，其中3例甚至发展为脑积水。死亡率为29%。
我们的研究结果表明，李斯特菌病可能成为台湾新生儿面临的一项重要健康威胁。
