从科氏蛇（Pseudechis colletti）毒液中分离出的磷脂酶A2所诱导的病理变化：光镜和电镜研究

Pathologic changes induced by phospholipase A2 isolated from the venom of Collett's snake, Pseudechis colletti: a light and electron microscopic study.

作者信息

Weinstein S A, Bell R C, Brown C R, Fletcher J E, Smith L A

机构信息

Department of Toxinology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011.

出版信息

Toxicon. 1992 Feb;30(2):171-85. doi: 10.1016/0041-0101(92)90470-p.

DOI:10.1016/0041-0101(92)90470-p

PMID:1557787

Abstract

Pseudechis colletti is an Australian elapid snake with a range limited to central Queensland, Australia. The venom of this snake, as well as that of several other Australian elapids, has been shown to contain a phospholipase A2 (PLA2) which can cause a marked myoglobinuria in mice. Few studies have described the histopathologic and ultrastructural changes that result from myotoxic PLA2-induced damage. Our investigation demonstrated that the isolated PLA2 induced myodegeneration and necrosis in myocardium in a dose-related manner, with subsequent myoglobinuria and myoglobinuric nephropathy.

摘要

柯氏拟眼镜蛇是一种澳大利亚眼镜蛇科蛇类，其分布范围仅限于澳大利亚昆士兰州中部。已证明这种蛇以及其他几种澳大利亚眼镜蛇科蛇类的毒液中含有一种磷脂酶A2（PLA2），该酶可在小鼠体内引起明显的肌红蛋白尿。很少有研究描述由肌毒性PLA2诱导损伤所导致的组织病理学和超微结构变化。我们的研究表明，分离出的PLA2以剂量相关的方式诱导心肌发生肌纤维变性和坏死，随后出现肌红蛋白尿和肌红蛋白尿性肾病。