Moffat B A, Hall D E, Stojanovska J, McConville P J, Moody J B, Chenevert T L, Rehemtulla A, Ross B D
Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, Ann Arbor, MI, 48109-0503, USA.
MAGMA. 2004 Dec;17(3-6):249-59. doi: 10.1007/s10334-004-0079-z. Epub 2004 Dec 1.
The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.
用于治疗实体瘤的新型靶向疗法不断发展，这就需要开发技术来确定其在临床前动物模型中的疗效。扩散磁共振成像（diffusion MRI）就是这样一种技术，它可以非侵入性地量化有效治疗导致的肿瘤细胞密度早期变化。在本综述中，我们提出了一些关于肿瘤治疗导致扩散变化起源的理论、获取表观扩散系数图的可靠方法，以及在多种治疗方案和动物模型中确定治疗效果的一些应用。
