Holtmann Gerald, Maldonado-Lopez Evelyn, Haag Sebastian
Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany.
J Gastroenterol. 2004 Nov;39(11):1027-34. doi: 10.1007/s00535-004-1440-8.
Heartburn is a common physiological event often associated with an underlying occurrence of gastroesophageal reflux disease (GERD). Studies show that GERD is a highly prevalent and chronic condition that significantly impacts on the patient's quality of life (QoL) and, in the long term, increases the risk for developing esophageal adenocarcinoma, more commonly referred to as Barrett's esophagus. Data indicate that symptom severity is a poor predictor of either the presence of erosive mucosal lesions or the development of complications. Given that lifestyle modifications are often insufficient for long-term treatment of GERD, drugs that inhibit gastric acid production--such as the proton pump inhibitors (PPIs)--are now the most effective strategy. Although generally well tolerated, the potential of PPIs for interactions with other drugs needs to be considered. This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting.
胃灼热是一种常见的生理现象，常与胃食管反流病（GERD）的潜在发生相关。研究表明，GERD是一种高度普遍的慢性疾病，会显著影响患者的生活质量（QoL），从长远来看，还会增加患食管腺癌（更常见的称为巴雷特食管）的风险。数据表明，症状严重程度并不能很好地预测是否存在糜烂性黏膜病变或并发症的发生。鉴于生活方式的改变通常不足以长期治疗GERD，抑制胃酸分泌的药物——如质子泵抑制剂（PPI）——现在是最有效的治疗策略。尽管PPI通常耐受性良好，但仍需考虑其与其他药物相互作用的可能性。本综述讨论了与GERD相关的症状和危险因素、与幽门螺杆菌感染的可能联系以及基层医疗环境中的有效治疗策略。
