Hosoe Tomoo, Fukushima Kazutaka, Itabashi Takeshi, Nozawa Koohei, Takizawa Kayoko, Okada Kaoru, Takaki Galba Maria de Campos, Kawai Ken-ichi
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
J Antibiot (Tokyo). 2004 Sep;57(9):573-8. doi: 10.7164/antibiotics.57.573.
In the screening of searching for new antifungal agents, a new nonaride compound, dihydroepiheveadride (1), was isolated from unidentified fungus IFM 52672 as the most potent antifungal principle from this organism. The structure of 1 was established on the basis of spectroscopic and chemical investigation, as well as detailed comparison of the spectroscopic and physico-chemical data of the oxidized derivative (3) from 1 with those of heveadride (2). Compound 1 showed strong antifungal activity against various filamentous fungi including human pathogens Aspergillus fumigatus, Penicillium marneffei and Trichophyton spp. It also showed the growth inhibition activity against certain human pathogenic yeasts such as Trichosporon species, while it had weak or no antifungal activity against Candida spp. and Cryptococcus neoformans, and no antibacterial activity against Bacillus subtilis nor against Escherichia coli. The antifungal potencies of compounds 2 and 3 were found to be weaker than that of 1.
在筛选新型抗真菌剂的过程中，从一株未鉴定的真菌IFM 52672中分离出一种新的非芳基化合物二氢表橡胶硬脂酸（1），它是该生物体中最有效的抗真菌成分。通过光谱和化学研究，以及将1的氧化衍生物（3）的光谱和物理化学数据与橡胶硬脂酸（2）的相关数据进行详细比较，确定了1的结构。化合物1对包括人类病原体烟曲霉、马尔尼菲青霉和毛癣菌属在内的多种丝状真菌具有很强的抗真菌活性。它对某些人类致病酵母如丝孢酵母属也表现出生长抑制活性，而对念珠菌属和新型隐球菌的抗真菌活性较弱或无活性，对枯草芽孢杆菌和大肠杆菌也无抗菌活性。发现化合物2和3的抗真菌效力比1弱。
