采用芳香化酶抑制剂来曲唑治疗的低级别子宫内膜间质肉瘤。
Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole.
作者信息
Leunen M, Breugelmans M, De Sutter Ph, Bourgain C, Amy J J
机构信息
Department of Gynecology, Andrology and Obstetrics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
出版信息
Gynecol Oncol. 2004 Dec;95(3):769-71. doi: 10.1016/j.ygyno.2004.07.063.
BACKGROUND
Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.
CASE
A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.
CONCLUSION
To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.
背景
低级别子宫内膜间质肉瘤是一种惰性的类固醇反应性肿瘤。已有报道成功采用激素治疗，最常用的是醋酸甲地孕酮。
病例
一名76岁女性25年前因良性疾病接受了全腹子宫切除术及双侧输卵管卵巢切除术。她因肾后性肾衰竭和巨大盆腔肿物压迫双侧输尿管前来就诊。经阴道肿物槽形活检后，诊断为低级别子宫内膜间质肉瘤，α-雌激素受体高表达。该患者仅接受来曲唑治疗，反应显著。
结论
据我们所知，这是首例将来曲唑长期用作复发性低级别间质肉瘤一线激素治疗的病例。
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