Reelin糖蛋白：结构、生物学特性及其在健康与疾病中的作用

Reelin glycoprotein: structure, biology and roles in health and disease.

作者信息

Fatemi S H

机构信息

Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA.

出版信息

Mol Psychiatry. 2005 Mar;10(3):251-7. doi: 10.1038/sj.mp.4001613.

DOI:10.1038/sj.mp.4001613

PMID:15583703

Abstract

Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.

摘要

Reelin糖蛋白是一种分泌性丝氨酸蛋白酶，在哺乳动物大脑中具有双重作用：在胚胎发育阶段，它引导神经元和放射状胶质细胞在发育中的大脑中到达其正确位置；在成人大脑中，Reelin参与一种信号通路，该通路是神经传递、记忆形成和突触可塑性的基础。Reln基因启动子的突变、选择性高甲基化或在各种产前或产后损伤后，Reelin信号通路的破坏可能导致自闭症或精神分裂症等神经精神疾病中出现的认知缺陷。