结肠癌细胞系中的I型干扰素抗性与体内更具侵袭性的表型相关。
Type I interferon resistance in a colorectal cancer cell line is associated with a more aggressive phenotype in vivo.
作者信息
Toth C A, Thomas P
机构信息
Laboratory of Cancer Biology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Br J Cancer. 1992 Mar;65(3):365-8. doi: 10.1038/bjc.1992.74.
Abstract
A type I interferon resistant variant (beta-MIP101) of the poorly differentiated human colon cancer cell MIP101 has a more aggressive phenotype in vivo in the nude mouse. Subcutaneous tumours grew at twice the rate of MIP101, but with similar morphology. beta-MIP101 also produced liver metastases at a higher frequency. beta-MIP101 tumours were diploid while MIP101 tumours were aneuploid. Both cell lines had doubling times of approximately 25 h in vitro.
摘要
低分化人结肠癌细胞MIP101的I型干扰素抗性变体（β-MIP101）在裸鼠体内具有更具侵袭性的表型。皮下肿瘤生长速度是MIP101的两倍，但形态相似。β-MIP101产生肝转移的频率也更高。β-MIP101肿瘤为二倍体，而MIP101肿瘤为非整倍体。两种细胞系在体外的倍增时间均约为25小时。
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