α干扰素和γ干扰素对体外培养或在裸鼠体内作为异种移植物生长的人肺癌细胞的作用。
The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
作者信息
Twentyman P R, Workman P, Wright K A, Bleehen N M
出版信息
Br J Cancer. 1985 Jul;52(1):21-9. doi: 10.1038/bjc.1985.143.
Abstract
We have compared the effects of alpha and recombinant gamma interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensitive being COR-L23 (a large cell anaplastic carcinoma line) and POC (a small cell line). In these two lines, IFN-gamma was found to be more potent than IFN-alpha. During cell growth of line POC in the presence of IFN-gamma no significant shift in cell cycle distribution occurred. When lines COR-L23 and POC were grown as xenograft tumours in nude mice, daily injection of 4 X 10(5) units per mouse per day of IFN-gamma produced no discernible retardation of tumour growth.
摘要
我们比较了α干扰素和重组γ干扰素（IFN）对人肺癌细胞系体外生长的影响。在所研究的细胞系中存在反应差异，最敏感的是COR-L23（一种大细胞间变性癌系）和POC（一种小细胞系）。在这两个细胞系中，发现γ干扰素比α干扰素更有效。在γ干扰素存在的情况下POC细胞系生长过程中，细胞周期分布未发生明显变化。当COR-L23和POC细胞系作为异种移植肿瘤在裸鼠体内生长时，每天每只小鼠注射4×10⁵单位的γ干扰素未产生明显的肿瘤生长迟缓。
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