Côté A, Blanchard P W, Meehan B
Jeremy Rill Clinical and Research Centre for Sudden Infant Death Syndrome and Apnea, Department of Pediatrics, Montreal Children's Hospital-Research Institute, McGill University, Montreal, Quebec, Canada.
J Appl Physiol (1985). 1992 Feb;72(2):410-5. doi: 10.1152/jappl.1992.72.2.410.
To evaluate the contribution of a change in metabolic rate to ventilatory changes after the administration of respiratory stimulants, we studied the effect of two respiratory stimulants, doxapram and theophylline, on ventilation and metabolic rate during sleep in piglets. Metabolic rate (O2 consumption and CO2 production) was measured in a metabolic chamber, and alveolar ventilation (VA) was derived from arterial PCO2 and CO2 production. We studied the animals during a baseline period and for 2 h after the administration of theophylline or doxapram. With doxapram, there was no change in VA, metabolic rate, or arterial PCO2. In contrast, with theophylline, VA increased [20 +/- 14% (SD), P less than 0.003] as a result of both an increased metabolic rate and hyperventilation. Doxapram, however, increased mean blood pressure (from 67 +/- 11 to 75 +/- 13 mmHg, P less than 0.005), whereas theophylline did not result in blood pressure changes. In summary, during quiet sleep, doxapram, unlike theophylline, does not stimulate either respiration or metabolic rate. We speculate that the previous reports of increased ventilation after the administration of doxapram are due to the general stimulation of activity in the awake state, an effect not seen during sleep.
为了评估代谢率变化对给予呼吸兴奋剂后通气变化的作用，我们研究了两种呼吸兴奋剂多沙普仑和茶碱对仔猪睡眠期间通气和代谢率的影响。在代谢室中测量代谢率（耗氧量和二氧化碳产生量），并根据动脉血二氧化碳分压和二氧化碳产生量推算肺泡通气量（VA）。我们在基线期以及给予茶碱或多沙普仑后2小时对动物进行研究。使用多沙普仑时，VA、代谢率或动脉血二氧化碳分压均无变化。相比之下，使用茶碱时，由于代谢率增加和通气过度，VA增加了[20±14%（标准差），P<0.003]。然而，多沙普仑使平均血压升高（从67±11 mmHg升至75±13 mmHg，P<0.005），而茶碱未导致血压变化。总之，在安静睡眠期间，与茶碱不同，多沙普仑不会刺激呼吸或代谢率。我们推测，之前关于给予多沙普仑后通气增加的报道是由于在清醒状态下对活动的普遍刺激，而在睡眠期间未观察到这种效应。
