Nishino T, Mokashi A, Lahiri S
J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1261-5. doi: 10.1152/jappl.1982.52.5.1261.
Small doses of doxapram (less than 0.5 mg . kg-1 iv) were used to study its effect on carotid chemoreceptor activity and ventilation in cats anesthesized with alpha-chloralose. The effects were studied at several levels of partial pressures of O2 and CO2 in arterial blood (PaO2 and PaCO2). It was found that doxapram stimulated discharge rate of the carotid chemoreceptor afferents by the same magnitude at all levels of PaO2 and PaCO2 studied. However, the ventilatory effect of doxapram was more than additive to the concomitant stimulation by hypoxia or hypercapnia. This ventilatory effect was eliminated by sectioning the carotid sinus and aortic nerves. These results led to the conclusion that the ventilatory stimulus interaction due to doxapram is dependent on the excitatory input from the peripheral chemoreceptors.
使用小剂量多沙普仑（静脉注射剂量小于0.5毫克·千克-1）来研究其对用α-氯醛糖麻醉的猫的颈动脉化学感受器活性和通气的影响。在动脉血中氧气和二氧化碳的几个分压水平（动脉血氧分压和动脉血二氧化碳分压）下研究了这些影响。发现在所研究的所有动脉血氧分压和动脉血二氧化碳分压水平下，多沙普仑刺激颈动脉化学感受器传入神经的放电率幅度相同。然而，多沙普仑的通气作用比低氧或高碳酸血症伴随刺激的作用更强。切断颈动脉窦和主动脉神经可消除这种通气作用。这些结果得出结论，多沙普仑引起的通气刺激相互作用依赖于来自外周化学感受器的兴奋性输入。
