Walsh Declan
The Harry R. Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA.
Support Care Cancer. 2005 Mar;13(3):138-44. doi: 10.1007/s00520-004-0743-x. Epub 2004 Dec 14.
Newly developed opioid analgesics and drug delivery systems may provide pain relief for patients intolerant of morphine. Long-acting oral opioids supply satisfactory analgesia at more convenient dosing intervals. Implantable pumps can provide full analgesic doses of opioids both subcutaneously and intrathecally over extended time periods. Optimal opioid use should rely on individualized dose-finding approaches to enhance pain relief while limiting drug-related side effects and avoiding the common problems associated with opioid prescription in clinical practice.
新研发的阿片类镇痛药和给药系统可能为不耐受吗啡的患者提供疼痛缓解。长效口服阿片类药物在更方便的给药间隔下提供令人满意的镇痛效果。植入式泵可在较长时间段内皮下和鞘内提供全剂量的阿片类镇痛药。最佳的阿片类药物使用应依赖个体化的剂量确定方法，以增强疼痛缓解效果，同时限制药物相关副作用，并避免临床实践中与阿片类药物处方相关的常见问题。
