Agnati L F, Genedani S, Lenzi P L, Leo G, Mora F, Ferré S, Fuxe K
Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
J Neural Transm (Vienna). 2005 Jan;112(1):45-63. doi: 10.1007/s00702-004-0180-5. Epub 2004 Jul 7.
The present paper enlightens a new point of view on brain homeostasis and communication, namely how the brain takes advantage of different chemical-physical phenomena such as pressure waves, and temperature and concentration gradients to allow the renewal of the extra-cellular fluid (i.e., the homeostasis of the brain internal milieu) as well as some forms of intercellular communications (Volume Transmission) at an energy cost much lower than the classical synaptic transmission (the prototype of Wiring Transmission). In particular, the possible functional meaning of the intracranial pressure waves is discussed in the frame of the so called "tide hypothesis" which maintains that the pressure waves, created by the cardiac pump, modulate the cerebro-spinal fluid flow from and towards the subarachnoid space as well as towards and from the Virchow-Robin spaces. These fluid push-pull movements favor both the migration of signals and the extra-cellular fluid renewal, especially in the cerebral cortex.
本文提出了关于脑内稳态与通讯的新观点，即大脑如何利用不同的化学物理现象，如压力波、温度和浓度梯度，以远低于经典突触传递（线路传递的原型）的能量成本，实现细胞外液的更新（即脑内环境的稳态）以及某些形式的细胞间通讯（容积传递）。特别地，颅内压力波的可能功能意义在所谓的“潮汐假说”框架下进行了讨论，该假说认为由心脏泵产生的压力波调节脑脊液进出蛛网膜下腔以及进出维氏-罗宾间隙的流动。这些液体的推拉运动有利于信号的传递和细胞外液的更新，尤其是在大脑皮层。
