Inserm-U751, Université de la Méditerranée, 13005 Marseille, France.
Trends Pharmacol Sci. 2010 Sep;31(9):394-401. doi: 10.1016/j.tips.2010.06.005. Epub 2010 Jul 14.
The energy demands of the brain are exceptionally high compared with any other organ of the body. A complex control system maintains brain energy homeostasis, mobilizing appropriate energy substrates to satisfy the energy requirements. It is a common belief that many fundamental neuronal properties, including those governing excitability, are dependent on the energy supply. However, surprisingly little is known about how the specific factors underlying neuronal activity are affected by energy status. Most of these parameters have been studied in acute brain slices, in which the homeostatic system is absent and neurons in the artificial extracellular milieu are arbitrarily supplied with energy substrates. In this paper, we discuss the relationships between availability of energy substrates and neuronal excitability, and suggest that for in vitro studies, it is crucial to optimize the composition of the energy pool in the extracellular milieu.
与身体的任何其他器官相比，大脑的能量需求异常高。一个复杂的控制系统维持着大脑的能量平衡，动员适当的能量底物来满足能量需求。人们普遍认为，许多基本的神经元特性，包括那些控制兴奋性的特性，都依赖于能量供应。然而，令人惊讶的是，人们对能量状态如何影响神经元活动的具体因素知之甚少。这些参数中的大多数都在急性脑切片中进行了研究，在急性脑切片中，不存在体内平衡系统，并且人工细胞外环境中的神经元可以任意获得能量底物。在本文中，我们讨论了能量底物的可获得性与神经元兴奋性之间的关系，并提出对于体外研究，优化细胞外环境中能量池的组成至关重要。
