Mayr A, Kirchmair M, Rainer J, Rossi R, Kreczy A, Tintelnot K, Dierich M P, Lass-Flörl C
Department of Hygiene and Social Medicine, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria.
Eur J Clin Microbiol Infect Dis. 2004 Dec;23(12):916-9. doi: 10.1007/s10096-004-1239-9.
Presented here is a case of chronic paracoccidioidomycosis that occurred in a Cuban female living in Austria and was first misdiagnosed as tuberculosis. The clinical picture was one of progressive pulmonary insufficiency with fever, weight loss and productive cough. Since antituberculous therapy was started but did not achieve a long-term clinical response, an intensive diagnostic work-up was performed. Paracoccidioides brasiliensis was then diagnosed by histopathology, serology, microbiology and molecular identification. Antifungal therapy was commenced immediately with amphotericin B (1 mg/kg/day) for 10 days, followed by voriconazole (200 mg/day po) for at least 3 months, and the lesions disappeared almost completely. This report presents the first published case of imported paracoccidioidomycosis in a female patient in Austria.
本文介绍了一例慢性副球孢子菌病病例，患者为一名居住在奥地利的古巴女性，最初被误诊为肺结核。临床表现为进行性肺功能不全，伴有发热、体重减轻和咳痰。由于开始了抗结核治疗但未取得长期临床疗效，因此进行了深入的诊断检查。随后通过组织病理学、血清学、微生物学和分子鉴定确诊为巴西副球孢子菌。立即开始使用两性霉素B（1mg/kg/天）进行抗真菌治疗，持续10天，随后使用伏立康唑（200mg/天口服）至少3个月，病变几乎完全消失。本报告介绍了奥地利首例已发表的女性患者输入性副球孢子菌病病例。
