Skyschally Andreas, Schulz Rainer, Haude Michael, Erbel Raimund, Heusch Gerd
Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum, Essen.
Herz. 2004 Dec;29(8):777-81. doi: 10.1007/s00059-004-2624-y.
Atherosclerotic plaque rupture is a key event in the pathogenesis of acute coronary syndromes and during coronary interventions. Atherosclerotic plaque rupture does not necessarily lead to thrombotic occlusion of a coronary artery and subsequent myocardial infarction. Milder forms may result in the embolization of atherosclerotic and/or thrombotic debris into the coronary microcirculation. The characteristic consequences of coronary microembolization are arrhythmias, microinfarcts, and a reduced coronary reserve. Experimental studies revealed that an inflammatory reaction is causally involved in the progressive contractile dysfunction following coronary microembolization. Thus, anti-inflammatory treatment appears as a promising strategy to protect patients from the consequences of coronary microembolization.
动脉粥样硬化斑块破裂是急性冠状动脉综合征发病机制以及冠状动脉介入治疗过程中的关键事件。动脉粥样硬化斑块破裂不一定会导致冠状动脉血栓性闭塞及随后的心肌梗死。较轻的形式可能导致动脉粥样硬化和/或血栓碎片栓塞到冠状动脉微循环中。冠状动脉微栓塞的典型后果是心律失常、微梗死和冠状动脉储备降低。实验研究表明，炎症反应与冠状动脉微栓塞后逐渐出现的收缩功能障碍有因果关系。因此，抗炎治疗似乎是一种有前景的策略，可以保护患者免受冠状动脉微栓塞后果的影响。
