Besic Nikola, Hocevar Marko, Zgajnar Janez, Pogacnik Ana, Grazio-Frkovic Snjezana, Auersperg Marija
Department of Surgery, Institute of Oncology, Zaloska 2, 1000, Ljubljana, Slovenia.
Langenbecks Arch Surg. 2005 Jun;390(3):203-8. doi: 10.1007/s00423-004-0524-5. Epub 2004 Dec 15.
Multivariate studies concerning the prognosis of patients with anaplastic carcinoma of the thyroid gland are scarce. The aim of our study was to determine the prognostic factors associated with survival of patients with anaplastic carcinoma in Slovenia, an iodine-deficient region.
This retrospective study was carried out on a group of 188 patients (130 female, 58 male; median age 68 years) with anaplastic carcinoma of the thyroid who had been treated at a tertiary care centre from 1972 to 2003. For each patient, data on gender, age, disease history, extent of disease, morphological characteristics, mode of therapy, and survival were collected. Statistical correlation between possible prognostic factors and survival was analysed by univariate and Cox's multivariate analysis. Treatment modality was not included in the analysis to avoid selection bias.
The median survival of all the patients was 3 (+/-0.36) months. Overall 1-year survival of our patients was 13%, and 2-year survival was 6%. Multivariate analysis showed that the patients' age, performance status, tumour growth, tumour extension and distant metastases were independent prognostic factors for the survival.
Patients younger than 71 years, with a good performance status and slowly growing tumours confined to the thyroid, and without distant metastases, had the best prognosis.
关于甲状腺间变性癌患者预后的多因素研究较少。我们研究的目的是确定在碘缺乏地区斯洛文尼亚，与甲状腺间变性癌患者生存相关的预后因素。
这项回顾性研究针对1972年至2003年在一家三级护理中心接受治疗的188例甲状腺间变性癌患者（130例女性，58例男性；中位年龄68岁）进行。收集了每位患者的性别、年龄、疾病史、疾病范围、形态学特征、治疗方式和生存数据。通过单因素分析和Cox多因素分析来分析可能的预后因素与生存之间的统计学相关性。分析中未纳入治疗方式以避免选择偏倚。
所有患者的中位生存期为3（±0.36）个月。我们患者的总体1年生存率为13%，2年生存率为6%。多因素分析表明，患者的年龄、体能状态、肿瘤生长、肿瘤范围和远处转移是生存的独立预后因素。
年龄小于71岁、体能状态良好、肿瘤生长缓慢且局限于甲状腺且无远处转移的患者预后最佳。
