King Mary Lou, Messitt Timothy J, Mowry Kimberly L
Department of Cell Biology and Anatomy, University of Miami School of Medicine, 1011 NW 15th St., Miami, FL 33136, USA.
Biol Cell. 2005 Jan;97(1):19-33. doi: 10.1042/BC20040067.
Localization of maternal mRNAs in many developing organisms provides the basis for both initial polarity during oogenesis and patterning during embryogenesis. Prominent examples of this phenomenon are found in Xenopus laevis, where localized maternal mRNAs generate developmental polarity along the animal/vegetal axis. Targeting of mRNA molecules to specific subcellular regions is a fundamental mechanism for spatial regulation of gene expression, and considerable progress has been made in defining the underlying molecular pathways.
在许多发育中的生物体中，母体mRNA的定位为卵子发生过程中的初始极性和胚胎发生过程中的模式形成提供了基础。这种现象的突出例子见于非洲爪蟾，其中定位的母体mRNA沿动物/植物轴产生发育极性。将mRNA分子靶向特定亚细胞区域是基因表达空间调控的基本机制，并且在确定潜在分子途径方面已经取得了相当大的进展。
