McManus Terence E, McDowell Andrew, Moore John E, Elborn Stuart J
Regional Adult Cystic Fibrosis Center, Belfast City Hospital, Belfast, Northern Ireland, BT9 7AB, UK.
Ann Clin Microbiol Antimicrob. 2004 Dec 15;3:26. doi: 10.1186/1476-0711-3-26.
Patients with cystic fibrosis [CF] have frequent pulmonary exacerbations associated with the isolation of bacterial organisms from sputum samples. It is not clear however, if there are differences in the types of additional organisms isolated from patients who are infected with Burkholderia cepacia complex [BCC] or Pseudomonas aerugionsa [PA] in comparison to those who are not infected with either of these organisms [NI].
Adult patients attending the regional CF unit were followed over a two year period and patients were assigned to three groups depending on whether they were known to be chronically infected with BCC, PA or NI. We compared the numbers and types of organisms which were isolated in each of these groups.
Information was available on a total of 79 patients; BCC 23, PA 30 and NI 26. Total numbers of organisms isolated, expressed as median and IQR for each group, [P = 0.045] and numbers of co-infecting organisms [P = 0.003] were significantly higher in the BCC group compared to PA, and in the PA group [P < 0.001, p = 0.007 respectively] compared to NI patients. The pattern of co-infecting organisms was similar in all three groups.
Total numbers of organisms isolated and numbers of co-infecting organisms were significantly higher in the BCC group compared to PA, and in the PA group compared to NI patients. Types of co-infecting organisms are similar in all groups of patients.
囊性纤维化（CF）患者经常出现肺部病情加重，且痰标本中可分离出细菌。然而，与未感染洋葱伯克霍尔德菌复合体（BCC）或铜绿假单胞菌（PA）的患者相比，从感染这两种细菌的患者中分离出的其他生物体类型是否存在差异尚不清楚。
对在地区CF治疗中心就诊的成年患者进行了为期两年的随访，并根据患者是否已知长期感染BCC、PA或未感染（NI）将其分为三组。我们比较了这三组中分离出的生物体数量和类型。
共有79例患者的信息可供分析，其中BCC组23例，PA组30例，NI组26例。以每组的中位数和四分位间距表示的分离出的生物体总数，[P = 0.045]以及合并感染生物体的数量[P = 0.003]，BCC组显著高于PA组，PA组与NI组患者相比也显著更高（分别为P < 0.001，p = 0.007）。所有三组中合并感染生物体的模式相似。
与PA组相比，BCC组分离出的生物体总数和合并感染生物体数量显著更高，与NI组患者相比，PA组也显著更高。所有患者组中合并感染生物体的类型相似。
