Fonseca Rosalina, Nägerl U Valentin, Morris Richard G M, Bonhoeffer Tobias
Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 München-Martinsried, Germany.
Neuron. 2004 Dec 16;44(6):1011-20. doi: 10.1016/j.neuron.2004.10.033.
The persistence of synaptic potentiation in the hippocampus is known to depend on transcription and protein synthesis. We report here that, under regimes of reduced protein synthesis, competition between synapses for the relevant intracellular proteins can be demonstrated. Under such circumstances, the induction of additional protein synthesis-dependent long-term potentiation for a given set of postsynaptic neurons occurs at the expense of the maintenance of prior potentiation on an independent pathway. This new phenomenon, which we call "competitive maintenance," has important functional consequences, and it may be explained in terms of dynamic interactions between synapses and "plasticity factors" over extended periods of time.
已知海马体中突触增强的持续性依赖于转录和蛋白质合成。我们在此报告，在蛋白质合成减少的情况下，可以证明突触之间对相关细胞内蛋白质存在竞争。在这种情况下，给定一组突触后神经元诱导额外的蛋白质合成依赖性长时程增强是以牺牲独立通路中先前增强的维持为代价的。我们将这种新现象称为“竞争性维持”，它具有重要的功能后果，并且可以用突触与“可塑性因子”在较长时间内的动态相互作用来解释。
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