3-羟基黄嘌呤的酶促氧化生成3-羟基尿酸。
Enzymic oxidation of 3-hydroxyxanthine to 3-hydroxyuric acid.
作者信息
Bergmann F, Levene L
出版信息
Biochim Biophys Acta. 1977 Apr 12;481(2):359-63. doi: 10.1016/0005-2744(77)90269-8.
PMID:15604
Abstract
- Bovine milk xanthine oxidase (xanthine:oxygen oxidoreductase, EC 1.2.3.2) oxidises 3-hydroxyxanthine slowly to 3-hydroxyuric acid; the 1-methyl derivative of 3-hydroxyxanthine is attacked about twice as fast. 2. The pH optimum for the reaction of 2-hydroxyxanthine is near 5, i.e. the neutral form of this substrate is attacked much faster than the anion. Probably in the "active" form of the latter, the negative charge is located mainly in the imidazole ring, thus inhibiting nucleophilic attack at C-8.
摘要
- 牛乳黄嘌呤氧化酶（黄嘌呤：氧氧化还原酶，EC 1.2.3.2）将3-羟基黄嘌呤缓慢氧化为3-羟基尿酸；3-羟基黄嘌呤的1-甲基衍生物的反应速度约快两倍。2. 2-羟基黄嘌呤反应的最适pH接近5，即该底物的中性形式比阴离子形式的反应速度快得多。可能在后者的“活性”形式中，负电荷主要位于咪唑环上，从而抑制了对C-8的亲核攻击。
相似文献
1
Enzymic oxidation of 3-hydroxyxanthine to 3-hydroxyuric acid.3-羟基黄嘌呤的酶促氧化生成3-羟基尿酸。
Biochim Biophys Acta. 1977 Apr 12;481(2):359-63. doi: 10.1016/0005-2744(77)90269-8.
2
Oxidation of hypoxanthines, bearing 8-aryl or 8-pyridyl substituents, by bovine milk xanthine oxidase.牛乳黄嘌呤氧化酶对带有8-芳基或8-吡啶基取代基的次黄嘌呤的氧化作用。
Biochim Biophys Acta. 1977 Oct 13;484(2):275-89. doi: 10.1016/0005-2744(77)90084-5.
3
Oxidation of N-methyl substituted hypoxanthines, xanthines, purine-6,8-diones and the corresponding 6-thioxo derivatives by bovine milk xanthine oxidase.牛乳黄嘌呤氧化酶对 N-甲基取代次黄嘌呤、黄嘌呤、嘌呤-6,8-二酮及相应的 6-硫代氧代衍生物的氧化作用
Biochim Biophys Acta. 1976 May 13;429(3):672-88. doi: 10.1016/0005-2744(76)90316-8.
4
Influence of 8-substitutes on the oxidation of hypoxanthine and 6-thioxopurine by bovine milk xanthine oxidase.8-取代基对牛乳黄嘌呤氧化酶催化次黄嘌呤和6-硫代嘌呤氧化的影响。
Biochim Biophys Acta. 1977 Jan 11;480(1):39-46. doi: 10.1016/0005-2744(77)90318-7.
5
Oxidation of methyl derivatives of pteridin-4-one, lumazine and related pteridines by bovine milk xanthine oxidase.牛乳黄嘌呤氧化酶对蝶啶 -4- 酮、鲁米诺嗪及相关蝶啶的甲基衍生物的氧化作用。
Biochim Biophys Acta. 1977 Jan 11;480(1):21-38. doi: 10.1016/0005-2744(77)90317-5.
6
Effects of flavonoids on xanthine oxidation as well as on cytochrome c reduction by milk xanthine oxidase.黄酮类化合物对牛奶黄嘌呤氧化酶催化的黄嘌呤氧化以及细胞色素c还原的影响。
J Nutr Sci Vitaminol (Tokyo). 1986 Dec;32(6):635-42. doi: 10.3177/jnsv.32.635.
7
A kinetic study of hypoxanthine oxidation by milk xanthine oxidase.牛奶黄嘌呤氧化酶催化次黄嘌呤氧化的动力学研究。
Biochem J. 1988 Sep 15;254(3):829-33. doi: 10.1042/bj2540829.
8
Behavior of N-methylated allopurinols and related 4-thioxopyrazolo [3,4-d]pyrimidines towards bovine milk xanthine oxidase.N-甲基化别嘌呤醇及相关4-硫代吡唑并[3,4-d]嘧啶对牛乳黄嘌呤氧化酶的作用
Biochim Biophys Acta. 1979 Sep 12;570(1):215-20. doi: 10.1016/0005-2744(79)90217-1.
9
Kinetics and thermodynamics of the molecular mechanism of the reductive half-reaction of xanthine oxidase.黄嘌呤氧化酶还原半反应分子机制的动力学与热力学
Biochemistry. 1994 Aug 30;33(34):10305-12. doi: 10.1021/bi00200a010.
10
Reaction of 1-amino- and 1-chlorophthalazine with mammalian molybdenum hydroxylases in vitro.1-氨基和1-氯酞嗪与哺乳动物钼羟基化酶的体外反应。
Xenobiotica. 1987 Jan;17(1):17-24. doi: 10.3109/00498258709047171.
Zotero 插件