多效生长因子的表达与黑素细胞肿瘤进展及转移潜能相关。

Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential.

作者信息

Wu H, Barusevicius A, Babb J, Klein-Szanto A, Godwin A, Elenitsas R, Gelfand J M, Lessin S, Seykora J T

机构信息

Department of Pathology, Fox Chase Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

J Cutan Pathol. 2005 Feb;32(2):125-30. doi: 10.1111/j.0303-6987.2005.00282.x.

DOI:10.1111/j.0303-6987.2005.00282.x

PMID:15606670

Abstract

BACKGROUND

Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas.

METHODS

To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions.

RESULTS

Melanocytic nevi were consistently negative (n=58). In contrast, the great majority of metastatic melanomas were positive (33/34, 97%). The analysis of 34 primary melanomas demonstrated PTN positivity in 20 lesions while 14 lesions were negative. Within the primary melanomas, PTN immunoreactivity was associated with metastasis (p=0.0004) and decreased melanoma-related survival (p=0.0444). Univariate analysis of PTN immunoreactivity predicted an increased risk for metastasis (relative risk 9.1, p=0.003).

CONCLUSIONS

The results of this study confirm previous gene profiling data showing differential PTN expression between melanocytic nevi and melanomas. In addition, lesional PTN expression is associated with metastatic potential and may be a prognostic factor for melanomas.

摘要

背景

黑色素瘤和痣组织的基因表达谱分析表明，多效生长因子（PTN）在人类黑色素瘤中显著过表达。

方法

为进一步评估PTN在黑素细胞性病变中的表达，对一系列黑素细胞性病变进行了蛋白质免疫组织化学检测。

结果

黑素细胞痣始终呈阴性（n = 58）。相比之下，绝大多数转移性黑色素瘤呈阳性（33/34，97%）。对34例原发性黑色素瘤的分析显示，20个病变中PTN呈阳性，14个病变呈阴性。在原发性黑色素瘤中，PTN免疫反应性与转移相关（p = 0.0004），并降低了黑色素瘤相关生存率（p = 0.0444）。PTN免疫反应性的单因素分析预测转移风险增加（相对风险9.1，p = 0.003）。