格雷夫斯病的氧化应激外周参数：甲巯咪唑治疗对合并和不合并浸润性眼病患者的影响。
Oxidative stress peripheral parameters in Graves' disease: the effect of methimazole treatment in patients with and without infiltrative ophthalmopathy.
作者信息
Bednarek Janusz, Wysocki Henryk, Sowiński Jerzy
机构信息
Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.
出版信息
Clin Biochem. 2005 Jan;38(1):13-8. doi: 10.1016/j.clinbiochem.2004.09.015.
OBJECTIVES
The study was designed to estimate the influence of hyperthyroidism and antithyroid treatment on oxidative stress peripheral parameters in Graves' disease patients with and without infiltrative ophthalmopathy.
DESIGN AND METHODS
Free radical generation and scavenging plasma indices were determined in 47 patients with hyperthyroidism due to Graves' disease (22 with and 25 without infiltrative ophthalmopathy), as well as in 24 healthy volunteers after euthyroidism achievement with methimazole.
RESULTS
In the hyperthyroid patients, hydrogen peroxide, lipid hydroperoxides, thiobarbituric acid-reacting substances, ceruloplasmin, superoxide dismutase, and catalase were increased. Glutathione peroxidase and glutathione reductase, however, were reduced. Methimazole treatment resulted in all markers being normalized in the patients without infiltrative ophthalmopathy, yet oxidative stress was still present in the ophthalmopathy group.
CONCLUSION
We suggest that apart from the thyroid metabolic status influence, it is orbital inflammation that triggers changes in blood extracellular indices of reactive oxygen species metabolism.
目的
本研究旨在评估甲状腺功能亢进症及抗甲状腺治疗对伴有和不伴有浸润性眼病的格雷夫斯病患者氧化应激外周参数的影响。
设计与方法
测定了47例格雷夫斯病所致甲状腺功能亢进症患者（22例伴有浸润性眼病，25例不伴有浸润性眼病）以及24例服用甲巯咪唑后甲状腺功能恢复正常的健康志愿者的自由基生成和血浆清除指标。
结果
甲状腺功能亢进症患者的过氧化氢、脂质氢过氧化物、硫代巴比妥酸反应物质、铜蓝蛋白、超氧化物歧化酶和过氧化氢酶水平升高。然而，谷胱甘肽过氧化物酶和谷胱甘肽还原酶水平降低。甲巯咪唑治疗使无浸润性眼病患者的所有指标恢复正常，但眼病组仍存在氧化应激。
结论
我们认为，除了甲状腺代谢状态的影响外，眼眶炎症也会引发血液中活性氧代谢细胞外指标的变化。
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