Greiner Wolfgang, Weijnen Tom, Nieuwenhuizen Martin, Oppe Siem, Badia Xavier, Busschbach Jan, Buxton Martin, Dolan Paul, Kind Paul, Krabbe Paul, Ohinmaa Arto, Parkin David, Roset Montserat, Sintonen Harri, Tsuchiya Aki, de Charro Frank
Institut für Versicherungsbetriebslehre, University of Hanover, Germany.
Eur J Health Econ. 2003 Sep;4(3):222-31. doi: 10.1007/s10198-003-0182-5.
The EQ-5D questionnaire is a widely used generic instrument for describing and valuing health that was developed by the EuroQol Group. A primary objective of the EuroQol Group is the investigation of values for health states in the general population in different countries. As part of the EuroQol enterprise 11 population surveys were carried out in six Western European countries (Finland, Germany, The Netherlands, Spain, Sweden and the UK) to value health states as defined by the EQ-5D using a standardised visual analogue scale (EQ-5D VAS). This contribution reports how a European set of general population preference weights was derived from the data collected in the 11 valuation studies. The scores from this set of preference weights can be applied to generate a VAS-based weighted health status index for all the potential 243 EQ-5D health states for use in multi-national studies. To estimate the preference weights a multi-level regression analysis was performed on 82,910 valuations of 44 EQ-5D health states elicited from 6,870 respondents. Stable and plausible solutions were found for the model parameters. The R(2) value was 75%. The analysis showed that the major source of variance, apart from 'random error', was variance between individuals (28.3% of the total residual variance). These results suggest that VAS values for EQ-5D health states in six Western European countries can be described by a common model.
EQ-5D问卷是欧洲生活质量研究组开发的一种广泛用于描述和评估健康状况的通用工具。欧洲生活质量研究组的一个主要目标是调查不同国家普通人群对健康状态的估值。作为欧洲生活质量研究项目的一部分,在六个西欧国家(芬兰、德国、荷兰、西班牙、瑞典和英国)开展了11次人群调查,以使用标准化视觉模拟量表(EQ-5D VAS)对EQ-5D所定义的健康状态进行估值。本论文阐述了如何从这11项估值研究收集的数据中得出一套欧洲普通人群偏好权重。这套偏好权重的得分可用于生成基于VAS的加权健康状况指数,适用于所有243种潜在的EQ-5D健康状态,以供跨国研究使用。为了估计偏好权重,对从6870名受访者那里得到的44种EQ-5D健康状态的82910次估值进行了多层次回归分析。模型参数得出了稳定且合理的结果。R(2)值为75%。分析表明,除“随机误差”外,主要的方差来源是个体之间的方差(占总剩余方差的28.3%)。这些结果表明,六个西欧国家EQ-5D健康状态的VAS值可以用一个通用模型来描述。
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