Khan M A
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Rheum Dis Clin North Am. 1992 Feb;18(1):1-10.
Ankylosing spondylitis and related spondyloarthropathies form a family of rheumatic diseases that are characterized by inflammatory peripheral and axial arthritis, with predilection for sacroiliitis, and a remarkably strong association with a genetic marker, HLA-B27. The association with B27 has provided a great impetus to the epidemiologic studies of spondyloarthropathies and also helped broaden the clinical spectrum of these diseases. There are at least six subtypes of B27, and the x-ray crystallographic structure of the common B27 subtype (B*2705) is now known. Endogenous peptides bound in the B27 antigen-binding cleft have been isolated and all seem to be nonamers (i.e., nine amino acids long).
强直性脊柱炎及相关脊柱关节病是一类风湿性疾病，其特征为炎性外周和中轴关节炎，好发于骶髂关节炎，且与一种遗传标记物HLA - B27有显著的强关联。与B27的关联极大地推动了脊柱关节病的流行病学研究，也有助于拓宽这些疾病的临床谱。B27至少有六种亚型，目前已知常见B27亚型（B*2705）的X射线晶体结构。在B27抗原结合裂隙中结合的内源性肽已被分离出来，且似乎都是九聚体（即九个氨基酸长）。
