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Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study.强直性脊柱炎、银屑病关节炎和未分化脊柱关节炎是否与心血管事件风险增加相关？一项基于全国人群的前瞻性队列研究。
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Calcif Tissue Int. 2017 Aug;101(2):182-192. doi: 10.1007/s00223-017-0274-3. Epub 2017 Apr 18.
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Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.司库奇尤单抗，一种白细胞介素-17A 抑制剂，治疗强直性脊柱炎。
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无论 HLA-B27 如何，基因多态性对巴西人群脊柱关节炎免疫发病机制的影响。

Influence of and Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.

机构信息

Department of Medicine, Maringa State University, Maringá, PR, Brazil.

Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringá, PR, Brazil.

出版信息

Mediators Inflamm. 2018 Apr 19;2018:1395823. doi: 10.1155/2018/1395823. eCollection 2018.

DOI:10.1155/2018/1395823
PMID:29849482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5933012/
Abstract

BACKGROUND AND OBJECTIVES

Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of and genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in a mixed Brazilian population.

METHODS

Genotyping of -308 (rs1800629), -238 (rs361525), (rs2275913), (rs763780), and polymorphisms was performed in 243 patients with SpA and 210 controls from Southern Brazil using SSOP-Luminex (One Lambda) and PCR-SSP assays.

RESULTS

Significant associations were confirmed between the HLA-B27 marker and SpA, AS, and PsA diseases. While -308 (rs1800629) AA/GA, (rs2275913) AA/GA, and (rs763780) CC/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of , -238 (rs361525) GA/AA, (rs2275913) AA/GA, and (rs763780) genotypes was associated with PsA.

CONCLUSION

In this Brazilian population, and gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with overall SpA, and, specifically, with AS and PsA, regardless of gender and . However, future larger studies with different ethnicities may be necessary to confirm these genetic associations.

摘要

背景与目的

脊柱关节炎（SpA）是一组具有重叠临床特征、遗传易感性和发病机制的免疫介导的炎症性疾病。因此，我们通过病例对照研究，调查了在混合的巴西人群中， 和 基因的单核苷酸多态性是否与 SpA、强直性脊柱炎（AS）和银屑病关节炎（PsA）相关。

方法

采用 SSOP-Luminex（One Lambda）和 PCR-SSP 检测方法，对来自巴西南部的 243 例 SpA 患者和 210 例对照者的 -308（rs1800629）、-238（rs361525）、 （rs2275913）、 （rs763780）和 多态性进行基因分型。

结果

HLA-B27 标志物与 SpA、AS 和 PsA 疾病之间存在显著关联。虽然 -308（rs1800629）AA/GA、 （rs2275913）AA/GA 和 （rs763780）CC/TC 基因型频率与 SpA 和 AS 相关，在显性遗传模型中，无论性别如何，-238（rs361525）GA/AA、 （rs2275913）AA/GA 和 （rs763780）CC/TC 基因型与 PsA 相关。

结论

在巴西人群中，负责表达重要炎症细胞因子的 和 基因多态性与整体 SpA 相关，特别是与 AS 和 PsA 相关，而与性别和 无关。然而，可能需要未来进行更大规模的不同种族的研究来证实这些遗传关联。