Domínguez-Malagón Hugo, Cano-Valdez Ana María, Mosqueda-Taylor Adalberto, Hes Ondrej
Departamento de Patología, Instituto Nacional de Cancerologiía, México, DF.
Ann Diagn Pathol. 2004 Dec;8(6):325-32. doi: 10.1053/j.anndiagpath.2004.08.001.
Follicular dendritic cell sarcoma is a tumor of recent description and characterization; it is often underdiagnosed because it is easily confused with other entities. Three cases of follicular dendritic cell sarcoma are described in the present article. The first occurred in the parapharyngeal space in a 29-year-old woman who developed multiple recurrences over the span of 10 years. The second was located in the left tonsil in a 48-year-old man, and the third case developed in the parapharyngeal space in a 26-year-old man. All cases were positive for CD21 and CD35 and ultrastructurally they displayed a morphologic spectrum. The first case featured spindle cells with interdigitated long cell processes joined by well-developed desmosomes. In the other two cases there were round to ovoid cells with interwoven processes connected by occasional desmosomes. Including these three cases, a total of 20 follicular dendritic cell sarcoma of the pharyngeal region have been reported to date. The clinical behavior of these tumors is similar to other low-grade sarcomas.
滤泡性树突状细胞肉瘤是一种近期才得以描述和特征化的肿瘤；由于它容易与其他实体混淆，故常常被漏诊。本文描述了3例滤泡性树突状细胞肉瘤。第一例发生于一名29岁女性的咽旁间隙，在10年期间出现多次复发。第二例位于一名48岁男性的左侧扁桃体，第三例发生于一名26岁男性的咽旁间隙。所有病例的CD21和CD35均呈阳性，并且在超微结构上它们表现出形态学谱。第一例的特征为梭形细胞，具有由发育良好的桥粒连接的相互交错的长细胞突起。在另外两例中，有圆形至卵圆形细胞，具有由偶尔的桥粒连接的交织突起。包括这3例在内，迄今为止共报道了20例咽区滤泡性树突状细胞肉瘤。这些肿瘤的临床行为与其他低级别肉瘤相似。
