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1
Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.开发一种龙猫模型，以便在实验性中耳炎期间对生物发光的不可分型流感嗜血杆菌进行直接、连续的生物光子成像。
Infect Immun. 2005 Jan;73(1):609-11. doi: 10.1128/IAI.73.1.609-611.2005.
2
A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.唾液酸操纵子中的突变会减弱不可分型流感嗜血杆菌在中耳炎性龙猫模型中的生存能力。
Infect Immun. 2005 Jan;73(1):599-608. doi: 10.1128/IAI.73.1.599-608.2005.
3
Nonencapsulated Streptococcus pneumoniae causes otitis media during single-species infection and during polymicrobial infection with nontypeable Haemophilus influenzae.非包膜肺炎链球菌在单一物种感染以及与不可分型流感嗜血杆菌的混合感染期间会引发中耳炎。
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Morphological changes in the tympanic membrane associated with Haemophilus influenzae-induced acute otitis media in the chinchilla.与流感嗜血杆菌诱发的栗鼠急性中耳炎相关的鼓膜形态学变化
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Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.在病毒-细菌双重感染的栗鼠模型中，通过主动免疫和被动免疫预防不可分型流感嗜血杆菌引起的中耳炎的发生。
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Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media.磷酰胆碱可减轻早期炎症，并在中耳炎的栗鼠模型中促进不可分型流感嗜血杆菌86 - 028NP稳定生物膜群落的形成。
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Morphological changes in the round window membrane associated with Haemophilus influenzae-induced acute otitis media in the chinchilla.与流感嗜血杆菌诱导的栗鼠急性中耳炎相关的圆窗膜形态学变化
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Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.在中耳炎性栗鼠模型中体内诱导产生的不可分型流感嗜血杆菌基因表达
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Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model.在栗鼠模型中评估不可分型流感嗜血杆菌脂寡糖在鼻咽部定植及中耳炎发生发展过程中的相变
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Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.1型腺病毒与不可分型流感嗜血杆菌在实验性中耳炎栗鼠模型中的协同作用
Infect Immun. 1994 May;62(5):1710-8. doi: 10.1128/iai.62.5.1710-1718.1994.

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Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms.针对 DNABII 蛋白整合宿主因子（IHF）的抗体抑制窦道植入物生物膜。
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Nontypeable releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.非典型菌株通过 T4SS 样复合物和 IV 型菌毛机械装置的 ComE 释放 DNA 和 DNABII 蛋白。
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Ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzae.铁摄取调节蛋白及其在非典型流感嗜血杆菌发病机制中的作用。
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本文引用的文献

1
A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.唾液酸操纵子中的突变会减弱不可分型流感嗜血杆菌在中耳炎性龙猫模型中的生存能力。
Infect Immun. 2005 Jan;73(1):599-608. doi: 10.1128/IAI.73.1.599-608.2005.
2
Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment.在体内感染过程中对宿主与病原体相互作用进行同步分析，揭示了宿主急性期反应蛋白的局部诱导、一种新的细菌应激反应以及宿主造成的金属离子限制环境的证据。
Cell Microbiol. 2004 Sep;6(9):849-65. doi: 10.1111/j.1462-5822.2004.00407.x.
3
Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.在中耳炎性栗鼠模型中体内诱导产生的不可分型流感嗜血杆菌基因表达
Infect Immun. 2003 Jun;71(6):3454-62. doi: 10.1128/IAI.71.6.3454-3462.2003.
4
Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge.源自不可分型流感嗜血杆菌粘附素和脂蛋白D的免疫原特异性抗血清的被动转移可预防异源攻击后的中耳炎。
Infect Immun. 2000 May;68(5):2756-65. doi: 10.1128/IAI.68.5.2756-2765.2000.
5
Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.在病毒-细菌双重感染的栗鼠模型中，通过主动免疫和被动免疫预防不可分型流感嗜血杆菌引起的中耳炎的发生。
Infect Immun. 1999 Jun;67(6):2746-62. doi: 10.1128/IAI.67.6.2746-2762.1999.
6
Simultaneous monitoring of cell number and metabolic activity of specific bacterial populations with a dual gfp-luxAB marker system.使用双gfp-luxAB标记系统同时监测特定细菌群体的细胞数量和代谢活性。
Appl Environ Microbiol. 1999 Feb;65(2):813-21. doi: 10.1128/AEM.65.2.813-821.1999.
7
Engineering the luxCDABE genes from Photorhabdus luminescens to provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5 constructs.对来自发光杆菌的luxCDABE基因进行工程改造，以提供用于组成型和启动子探针质粒及mini-Tn5构建体的生物发光报告基因。
FEMS Microbiol Lett. 1998 Jun 15;163(2):193-202. doi: 10.1111/j.1574-6968.1998.tb13045.x.
8
Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.用于研究N-酰基高丝氨酸内酯介导的群体感应的基于luxCDABE的质粒传感器的构建与分析。
FEMS Microbiol Lett. 1998 Jun 15;163(2):185-92. doi: 10.1111/j.1574-6968.1998.tb13044.x.
9
Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.1型腺病毒与不可分型流感嗜血杆菌在实验性中耳炎栗鼠模型中的协同作用
Infect Immun. 1994 May;62(5):1710-8. doi: 10.1128/iai.62.5.1710-1718.1994.
10
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.不可分型流感嗜血杆菌表达的菌毛在中耳炎发病机制及预防中的作用以及菌毛蛋白亚基与外膜蛋白A的相关性
Infect Immun. 1994 May;62(5):2002-20. doi: 10.1128/iai.62.5.2002-2020.1994.

开发一种龙猫模型，以便在实验性中耳炎期间对生物发光的不可分型流感嗜血杆菌进行直接、连续的生物光子成像。

Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.

作者信息

Novotny Laura A, Mason Kevin M, Bakaletz Lauren O

机构信息

Center for Microbial Pathogenesis, Columbus Children's Research Institute, The Ohio State University College of Medicine and Public Health, Rm. W591, 700 Children's Dr., Columbus, OH 43205-2696, USA.

出版信息

Infect Immun. 2005 Jan;73(1):609-11. doi: 10.1128/IAI.73.1.609-611.2005.

DOI:10.1128/IAI.73.1.609-611.2005
PMID:15618201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC538955/
Abstract

We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.

摘要

我们用一个含有由流感嗜血杆菌外膜蛋白P2启动子驱动的luxCDABE操纵子的质粒转化了一株不可分型的流感嗜血杆菌临床分离株。在此，我们展示了在滴鼻和经鼓室攻击后，检测生物发光以及监测豚鼠鼻咽、咽鼓管和中耳内感染情况的能力。