Kwak Su-Hwan, Shen Ronglai, Schiefelbein John
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA.
Science. 2005 Feb 18;307(5712):1111-3. doi: 10.1126/science.1105373. Epub 2004 Dec 23.
The position-dependent specification of root epidermal cells in Arabidopsis provides an elegant paradigm for cell patterning during development. Here, we describe a new gene, SCRAMBLED (SCM), required for cells to appropriately interpret their location within the developing root epidermis. SCM encodes a receptor-like kinase protein with a predicted extracellular domain of six leucine-rich repeats and an intracellular serine-threonine kinase domain. SCM regulates the expression of the GLABRA2, CAPRICE, WEREWOLF, and ENHANCER OF GLABRA3 transcription factor genes that define the cell fates. Further, the SCM gene is expressed throughout the developing root. Therefore, SCM likely enables developing epidermal cells to detect positional cues and establish an appropriate cell-type pattern.
拟南芥根表皮细胞的位置依赖性特化，为发育过程中的细胞模式形成提供了一个精妙的范例。在此，我们描述了一个新基因——无序（SCM），它是细胞在发育中的根表皮内正确解读其位置所必需的。SCM编码一种类受体激酶蛋白，其预测的细胞外结构域有六个富含亮氨酸的重复序列，以及一个细胞内丝氨酸 - 苏氨酸激酶结构域。SCM调节定义细胞命运的GLABRA2、CAPRICE、WEREWOLF和GLABRA3增强子转录因子基因的表达。此外，SCM基因在整个发育中的根中都有表达。因此，SCM可能使发育中的表皮细胞能够检测位置线索并建立适当的细胞类型模式。
