Nadeau Jeanette A, Sack Fred D
Department of Plant Biology, Ohio State University, 1735 Neil Avenue, Columbus, OH 43210, USA.
Science. 2002 May 31;296(5573):1697-700. doi: 10.1126/science.1069596.
Stomata regulate gas exchange and are distributed across the leaf epidermis with characteristic spacing. Arabidopsis stomata are produced by asymmetric cell divisions. Mutations in the gene TOO MANY MOUTHS (TMM) disrupt patterning by randomizing the plane of formative asymmetric divisions and by permitting ectopic divisions. TMM encodes a leucine-rich repeat-containing receptor-like protein expressed in proliferative postprotodermal cells. TMM appears to function in a position-dependent signaling pathway that controls the plane of patterning divisions as well as the balance between stem cell renewal and differentiation in stomatal and epidermal development.
气孔调节气体交换，并以特定的间距分布在叶片表皮上。拟南芥的气孔由不对称细胞分裂产生。“过多口器”（TMM）基因的突变通过使形成性不对称分裂的平面随机化以及允许异位分裂来破坏模式形成。TMM编码一种富含亮氨酸重复序列的类受体蛋白，在增殖的原表皮后细胞中表达。TMM似乎在一个位置依赖性信号通路中发挥作用，该通路控制模式形成分裂的平面以及气孔和表皮发育中干细胞更新与分化之间的平衡。
