Degroot Aldemar, Wolff Mary C, Nomikos George G
Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285-0510, USA.
Neuroreport. 2005 Jan 19;16(1):63-7. doi: 10.1097/00001756-200501190-00015.
Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed to the toy showed a significant increase in hippocampal ACh efflux provided that they actively manipulated the object. Similarly, a single 1 h introduction of the novel object (toy) immediately after a training session in a radial arm maze significantly improved memory only if the animals actively manipulated the object. The data suggest that environmental enrichment during a critical period (consolidation) is sufficient to improve learning and memory. This effect is likely mediated through an enhancement of hippocampal cholinergic neurotransmission.
环境富集可增强啮齿动物和人类的学习与记忆能力。我们研究了主动操控一个新物体（玩具）对大鼠海马体认知表现及乙酰胆碱（ACh）外流的影响。只要动物主动操控该物体，接触玩具的动物海马体ACh外流就会显著增加。同样，在放射状臂迷宫训练后立即单次引入新物体（玩具）1小时，只有当动物主动操控该物体时，记忆才会显著改善。数据表明，关键期（巩固期）的环境富集足以改善学习和记忆。这种效应可能是通过增强海马体胆碱能神经传递介导的。
