Williams L A D, Rösner H, Möller W, Conrad J, Nkurunziza J P, Kraus W
The Institutes of Bio-organic Chemistry and Zoology, University of Hohenheim, Garbenstrasse 30, D-70593 Stuttgart, Germany.
West Indian Med J. 2004 Sep;53(4):208-19.
Sixty natural products belonging to the following structural classes: artemisinins, coumarins, flavonoids, tannins, tetrahydroberberine alkaloids, tetracyclic triterpenes, tetranortriterpenoids and polysulphides were screened against the human SH-SY5Y neuroblastoma cell line revealing differences in their effects on cell morphology and in anti-proliferation/cytotoxic activity. Based on the data obtained, dibenzyl trisulphide is the most effective anti-proliferative/cytotoxic compound. In addition, we hereby propose the human SH-SY5Y cell line as a sensitive and uncomplicated in vitro test system for detecting compounds with potential anti-proliferation/cytotoxic activity.
对属于以下结构类别的60种天然产物进行了筛选：青蒿素、香豆素、黄酮类化合物、单宁、四氢小檗碱生物碱、四环三萜、四环降三萜和多硫化物，以研究其对人SH-SY5Y神经母细胞瘤细胞系的影响，结果显示它们在细胞形态、抗增殖/细胞毒性活性方面存在差异。根据所得数据，二苄基三硫化物是最有效的抗增殖/细胞毒性化合物。此外，我们在此提出将人SH-SY5Y细胞系作为一种灵敏且简单的体外检测系统，用于检测具有潜在抗增殖/细胞毒性活性的化合物。
