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Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.

作者信息

Tang Jian, Li Hui-Liang, Shen Yun-Heng, Jin Hui-Zi, Yan Shi-Kai, Liu Run-Hui, Zhang Wei-Dong

机构信息

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

出版信息

Phytother Res. 2008 Aug;22(8):1093-6. doi: 10.1002/ptr.2463.

DOI:10.1002/ptr.2463
PMID:18570211
Abstract

The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Among these samples, CHCl(3) fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.

摘要

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