Liu X, Chen K, Shi H, Cai H, Li L, Lou J, Qian B
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
Zhonghua Xue Ye Xue Za Zhi. 1997 May;18(5):234-6.
To observe the effect of sodium iron chlorophyllin (SIC) on hematopoiesis and its therapeutic efficacy in anemic mice.
The effects of SIC on CFU-E and CFU-GM yields of normal and anemic animal models were studied.
(1) SIC significantly enhanced the CFU-E and CFU-GM yields of mouse bone marrow. (2) SIC also increased the percentage of reticulocyte in mouse. (3) In hemolytic anemia mice induced by i.p. N-acetphenylhydrazine, SIC markedly prevented the decrease of RBC and Hb. (4) In hemorrhagic anemia rats induced by bleedletting, SIC accelerated the normalization of RBC, Hb and elevated the serum iron level and transferrin saturation.
观察叶绿酸铁钠（SIC）对小鼠造血功能的影响及其对贫血小鼠的治疗效果。
研究SIC对正常及贫血动物模型的CFU-E和CFU-GM产量的影响。
（1）SIC显著提高小鼠骨髓CFU-E和CFU-GM产量。（2）SIC还增加了小鼠网织红细胞百分比。（3）在腹腔注射N-乙酰苯肼诱导的溶血性贫血小鼠中，SIC显著防止红细胞和血红蛋白减少。（4）在放血诱导的失血性贫血大鼠中，SIC加速红细胞、血红蛋白恢复正常，并提高血清铁水平和转铁蛋白饱和度。
