Carder P J, Speirs V, Ramsdale J, Lansdown M R J
J Clin Pathol. 2005 Jan;58(1):69-71. doi: 10.1136/jcp.2004.018291.
Male breast cancer is uncommon, accounting for less than 1% of all breast cancers. Carcinoma metastatic to the male breast is also unusual, with metastatic prostatic carcinoma being among the most common primary sites from which such tumours derive. Metastatic prostatic cancer and primary breast cancer may be histologically indistinguishable without immunohistochemistry because both often infiltrate with a cribriform architecture. Distinguishing between primary and metastatic disease within the breast is important because the treatment options for each are radically different. Following a case in which metastatic prostatic disease was initially wrongly diagnosed as primary breast cancer, a small series of male breast cancers was examined for expression of prostate specific antigen (PSA) and prostatic acid phosphatase to assess the usefulness of these markers in making this distinction. Focal expression of PSA was found in one of 11 cases of male breast cancer. These results indicate that PSA should be used with caution in this context.
男性乳腺癌并不常见，占所有乳腺癌的比例不到1%。转移至男性乳腺的癌也不常见，转移性前列腺癌是此类肿瘤最常见的原发部位之一。在没有免疫组化的情况下，转移性前列腺癌和原发性乳腺癌在组织学上可能无法区分，因为二者通常都呈筛状结构浸润。区分乳腺内的原发性和转移性疾病很重要，因为二者的治疗方案截然不同。在一例转移性前列腺疾病最初被误诊为原发性乳腺癌的病例之后，对一小系列男性乳腺癌进行了前列腺特异性抗原（PSA）和前列腺酸性磷酸酶表达检测，以评估这些标志物在进行这种区分时的实用性。在11例男性乳腺癌病例中，有1例发现PSA局灶性表达。这些结果表明，在这种情况下应谨慎使用PSA。
