θ频率刺激上调了从海马体CA1区到下托区通路的突触强度。
Theta frequency stimulation up-regulates the synaptic strength of the pathway from CA1 to subiculum region of hippocampus.
作者信息
Huang Yan-You, Kandel Eric R
机构信息
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.
出版信息
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):232-7. doi: 10.1073/pnas.0408368102. Epub 2004 Dec 27.
Abstract
The subiculum (SB) is the principal target of the axons of the CA1 pyramidal cells and serves as the final relay in the trisynaptic loop between the entorhinal cortex and the hippocampus. We have examined synaptic plasticity in the synaptic pathway between the CA1 pyramidal cells and the SB in hippocampal slices and compared it under the same experimental condition with the synaptic plasticity in Shaffer collateral pathway (CA3-CA1). We find that the frequency response curve of synaptic strength induced by prolonged low-frequency stimulation (1-5 Hz) is systematically up-shifted from Shaffer collateral to the CA1-SB pathway. The up-regulation of synaptic strength is mediated by the activity-dependent modulation by beta-adrenergic transmission. Because the CA3-CA1 and the CA1-SB synaptic pathways are in series and the beta-adrenergic modulation is region-specific, this modulation seems to be involved in the selective control of signal transmission between the different regions of hippocampus.
摘要
海马下脚（SB）是CA1锥体细胞轴突的主要靶标，并且在内嗅皮质与海马体之间的三突触回路中充当最终中继站。我们已经研究了海马切片中CA1锥体细胞与SB之间突触通路中的突触可塑性，并在相同实验条件下将其与谢弗侧支通路（CA3-CA1）中的突触可塑性进行了比较。我们发现，由长时间低频刺激（1-5赫兹）诱导的突触强度频率响应曲线从谢弗侧支向CA1-SB通路系统性地上移。突触强度的上调是由β-肾上腺素能传递的活动依赖性调节介导的。由于CA3-CA1和CA1-SB突触通路是串联的，并且β-肾上腺素能调节具有区域特异性，这种调节似乎参与了海马体不同区域之间信号传递的选择性控制。
相似文献
1
Theta frequency stimulation up-regulates the synaptic strength of the pathway from CA1 to subiculum region of hippocampus.θ频率刺激上调了从海马体CA1区到下托区通路的突触强度。
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):232-7. doi: 10.1073/pnas.0408368102. Epub 2004 Dec 27.
2
Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy.在毛果芸香碱癫痫模型中，β-肾上腺素能受体激活对海马输出的门控作用。
Neuroscience. 2015 Feb 12;286:325-37. doi: 10.1016/j.neuroscience.2014.11.055. Epub 2014 Dec 10.
3
A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus.一项关于海马体CA1锥体细胞上谢弗侧支突触θ周期期间可塑性的计算研究。
Hippocampus. 2015 Feb;25(2):208-18. doi: 10.1002/hipo.22365. Epub 2014 Sep 25.
4
Low-frequency stimulation of the temporoammonic pathway induces heterosynaptic disinhibition in the subiculum.颞眶通路的低频刺激诱导下托区的异突触抑制。
Hippocampus. 2011 Jul;21(7):733-43. doi: 10.1002/hipo.20791. Epub 2010 Apr 13.
5
Hippocampus as comparator: role of the two input and two output systems of the hippocampus in selection and registration of information.海马体作为比较器：海马体的两个输入和两个输出系统在信息选择与登记中的作用。
Hippocampus. 2001;11(5):578-98. doi: 10.1002/hipo.1073.
6
Target-cell-specific bidirectional synaptic plasticity at hippocampal output synapses.海马体输出突触处的靶细胞特异性双向突触可塑性。
Eur J Neurosci. 2008 Mar;27(5):1111-8. doi: 10.1111/j.1460-9568.2008.06089.x. Epub 2008 Feb 29.
7
Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum.使用笼锁谷氨酸的局灶性闪光光解的电生理证据表明，CA1锥体细胞从下托接受兴奋性突触输入。
J Neurophysiol. 2005 May;93(5):3007-11. doi: 10.1152/jn.00877.2004. Epub 2004 Dec 15.
8
Astrocyte calcium signals at Schaffer collateral to CA1 pyramidal cell synapses correlate with the number of activated synapses but not with synaptic strength.星型胶质细胞钙信号在 Schaffer 侧支到 CA1 锥体神经元突触处与激活的突触数量相关，而与突触强度无关。
Hippocampus. 2012 Jan;22(1):29-42. doi: 10.1002/hipo.20843. Epub 2010 Sep 29.
9
Synaptic plasticity in the hippocampal area CA1-subiculum projection: implications for theories of memory.海马体CA1区-下托投射中的突触可塑性：对记忆理论的启示
Hippocampus. 2000;10(4):447-56. doi: 10.1002/1098-1063(2000)10:4<447::AID-HIPO11>3.0.CO;2-2.
10
Proton radiation alters intrinsic and synaptic properties of CA1 pyramidal neurons of the mouse hippocampus.质子辐射会改变小鼠海马体CA1锥体神经元的内在特性和突触特性。
Radiat Res. 2015 Feb;183(2):208-18. doi: 10.1667/RR13785.1. Epub 2015 Jan 26.
引用本文的文献
1
Cholecystokinin facilitates the formation of long-term heterosynaptic plasticity in the distal subiculum.胆囊收缩素促进远端海马下托中长期异突触可塑性的形成。
Commun Biol. 2025 Feb 1;8(1):153. doi: 10.1038/s42003-025-07597-9.
2
Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory.锥体细胞与生长抑素中间神经元突触处的长时程增强作用控制着海马体网络可塑性和记忆。
iScience. 2022 Apr 13;25(5):104259. doi: 10.1016/j.isci.2022.104259. eCollection 2022 May 20.
3
Stress-Induced Enhanced Long-Term Potentiation and Reduced Threshold for N-Methyl-D-Aspartate Receptor- and β-Adrenergic Receptor-Mediated Synaptic Plasticity in Rodent Ventral Subiculum.应激诱导的长时程增强增强及啮齿动物腹侧海马下托中N-甲基-D-天冬氨酸受体和β-肾上腺素能受体介导的突触可塑性阈值降低
Front Mol Neurosci. 2021 Apr 22;14:658465. doi: 10.3389/fnmol.2021.658465. eCollection 2021.
4
Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum.从海马投射到下托的 mGluR8a 支配的 GABA 能三层细胞的突触组织和行为依赖性活动。
Brain Struct Funct. 2020 Mar;225(2):705-734. doi: 10.1007/s00429-020-02029-2. Epub 2020 Feb 3.
5
Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour.从常见的小鼠模型理解智力障碍和自闭症谱系障碍：从突触到行为。
Open Biol. 2019 Jun 28;9(6):180265. doi: 10.1098/rsob.180265. Epub 2019 Jun 12.
6
Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes.在前脑特异性敲除Stim基因的小鼠中，空间记忆受损且长时程增强作用增强。
Front Behav Neurosci. 2015 Jul 14;9:180. doi: 10.3389/fnbeh.2015.00180. eCollection 2015.
7
5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices.5-羟色胺4受体调节急性大鼠脑片中海马输出突触处的长时程抑制的诱导，但不调节其增强。
PLoS One. 2014 Feb 5;9(2):e88085. doi: 10.1371/journal.pone.0088085. eCollection 2014.
8
Acute stress and hippocampal output: exploring dorsal CA1 and subicular synaptic plasticity simultaneously in anesthetized rats.急性应激与海马输出：在麻醉大鼠中同时探索背侧CA1区和海马下脚的突触可塑性
Physiol Rep. 2013 Jul;1(2):e00035. doi: 10.1002/phy2.35. Epub 2013 Jul 21.
9
Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity in rat dorsal subiculum via glucocorticoid receptor activation.急性应激而非皮质酮通过激活糖皮质激素受体破坏大鼠背侧海马伞的短期和长期突触可塑性。
Cereb Cortex. 2013 Nov;23(11):2611-9. doi: 10.1093/cercor/bhs247. Epub 2012 Aug 23.
10
Neurophysiological correlates of object recognition in the dorsal subiculum.背侧海马下托中物体识别的神经生理相关性
Front Behav Neurosci. 2012 Jul 19;6:46. doi: 10.3389/fnbeh.2012.00046. eCollection 2012.
本文引用的文献
1
Long-term potentiation of single subicular neurons in mice.小鼠单个海马下托神经元的长期增强效应
Hippocampus. 2000;10(6):684-92. doi: 10.1002/1098-1063(2000)10:6<684::AID-HIPO1006>3.0.CO;2-H.
2
Synaptic plasticity in the hippocampal area CA1-subiculum projection: implications for theories of memory.海马体CA1区-下托投射中的突触可塑性：对记忆理论的启示
Hippocampus. 2000;10(4):447-56. doi: 10.1002/1098-1063(2000)10:4<447::AID-HIPO11>3.0.CO;2-2.
3
ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors.细胞外信号调节激酶（ERK）在θ波频率刺激诱导长时程增强（LTP）及其受β-肾上腺素能受体调节过程中发挥调控作用。
Neuron. 1999 Nov;24(3):715-26. doi: 10.1016/s0896-6273(00)81124-1.
4
The perforant path projection from the medial entorhinal cortex layer III to the subiculum in the rat combined hippocampal-entorhinal cortex slice.大鼠海马-内嗅皮层联合切片中，从内侧内嗅皮层III层到海马下脚的穿通通路投射。
Eur J Neurosci. 1998 Mar;10(3):1011-8. doi: 10.1046/j.1460-9568.1998.00111.x.
5
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates.目标导向的工具性动作：偶然性与激励学习及其皮质基质
Neuropharmacology. 1998 Apr-May;37(4-5):407-19. doi: 10.1016/s0028-3908(98)00033-1.
6
5-Hz stimulation of CA3 pyramidal cell axons induces a beta-adrenergic modulated potentiation at synapses on CA1, but not CA3, pyramidal cells.对CA3锥体细胞轴突进行5赫兹的刺激，会在CA1锥体细胞而非CA3锥体细胞的突触处诱导出一种β-肾上腺素能调节的突触增强效应。
Brain Res. 1998 May 25;794(1):75-9. doi: 10.1016/s0006-8993(98)00217-0.
7
Insights from in vivo modification of adrenergic receptor gene expression.肾上腺素能受体基因表达的体内修饰研究进展
Annu Rev Pharmacol Toxicol. 1998;38:351-73. doi: 10.1146/annurev.pharmtox.38.1.351.
8
Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region.海马CA1区中与活动相关的β-肾上腺素能对低频刺激诱导的长时程增强的调制作用。
Neuron. 1996 Sep;17(3):475-82. doi: 10.1016/s0896-6273(00)80179-8.
9
Spatial cognitive maps in animals: new hypotheses on their structure and neural mechanisms.动物的空间认知地图：关于其结构和神经机制的新假说
Psychol Rev. 1993 Apr;100(2):163-82. doi: 10.1037/0033-295x.100.2.163.
10
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.代谢型谷氨酸受体的激活通过增强对内源性腺苷的反应来增加海马体中的环磷酸腺苷积累。
J Neurosci. 1993 Jan;13(1):38-44. doi: 10.1523/JNEUROSCI.13-01-00038.1993.
Zotero 插件