Vogt S, Berger S, Wilke I, Larcher Y, Weisser J, Schnabelrauch M
INNOVENT Technologieentwicklung e.V., Pruessingstrasse 27B, D-07745 Jena, Germany.
Biomed Mater Eng. 2005;15(1-2):73-85.
Novel difunctional oligolactone macromers have been synthesized by ring-opening oligomerization of various lactones (L-lactide, glycolide, p-dioxanone) in the presence of suitable diols (propane-1,2-diol, dianhydro-D-glucitol) and subsequent endcapping of the formed oligolactones with methacrylate moieties. Based on these macromers, two fabrication procedures were developed to fabricate highly porous scaffolds and the material properties including in vitro biodegradation behaviour of the resulting polymeric scaffolds were investigated. Preliminary in vitro studies on the cytocompatibility of the fabricated scaffolds and on osteoblast cultivation on the optimized polymeric materials demonstrated that the oligolactide based polymer networks possess an excellent biocompatibility and that they are promising candidates as scaffolds in bone tissue engineering.
通过在合适的二醇（1,2 - 丙二醇、二脱水 - D - 葡萄糖醇）存在下使各种内酯（L - 丙交酯、乙交酯、对二氧环己酮）进行开环低聚反应，随后用甲基丙烯酸酯部分对形成的低聚内酯进行封端，合成了新型双官能低聚内酯大分子单体。基于这些大分子单体，开发了两种制备高度多孔支架的方法，并研究了所得聚合物支架的材料性能，包括其体外生物降解行为。对制备的支架的细胞相容性以及在优化的聚合物材料上培养成骨细胞的初步体外研究表明，基于低聚内酯的聚合物网络具有优异的生物相容性，并且它们有望成为骨组织工程中的支架材料。
