Brauer Delia S, Rüssel Christian, Vogt Sebastian, Weisser Jürgen, Schnabelrauch Matthias
Department of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
J Mater Sci Mater Med. 2008 Jan;19(1):121-7. doi: 10.1007/s10856-007-3147-x. Epub 2007 Jun 21.
The development of biodegradable materials for internal fracture fixation is of great interest, as they would both eliminate the problem of stress shielding and obviate the need for a second operation to remove fixation devices. Preliminary investigations for the production of degradable fiber reinforced polymer composite materials are detailed. Composites were produced of phosphate invert glass fibers of the glass system P(2)O(5)-CaO-MgO-Na(2)O-TiO(2), which showed a low solubility in previous work. The fibers were embedded into a matrix of a degradable organic polymer network based on methacrylate-modified oligolactide. Fracture behavior, bending strength and elastic modulus were evaluated during 3-point bending tests and the fracture surface of the composites was investigated using a scanning electron microscope. Short-term biocompatibility was tested in an FDA/EtBr viability assay using MC3T3-E1 murine pre-osteoblast cells and showed a good cell compatibility of the composite materials. Results suggested that these composite materials are biocompatible and show mechanical properties which are of interest for the production of degradable bone fixation devices.
用于内部骨折固定的可生物降解材料的开发备受关注，因为它们既能消除应力屏蔽问题，又无需二次手术来移除固定装置。本文详细介绍了可降解纤维增强聚合物复合材料生产的初步研究。复合材料由玻璃体系为P(2)O(5)-CaO-MgO-Na(2)O-TiO(2)的磷酸钙反玻璃纤维制成，在先前的研究中显示出低溶解性。这些纤维被嵌入到基于甲基丙烯酸酯改性低聚丙交酯的可降解有机聚合物网络基质中。在三点弯曲试验中评估了复合材料的断裂行为、弯曲强度和弹性模量，并使用扫描电子显微镜研究了复合材料的断裂表面。使用MC3T3-E1小鼠前成骨细胞在FDA/溴化乙锭活力测定中测试了短期生物相容性，结果表明复合材料具有良好的细胞相容性。结果表明，这些复合材料具有生物相容性，并且其机械性能对于生产可降解骨固定装置具有重要意义。
