Hagelin J
Synalsvagen 10, SE 757 57 Uppsala, Sweden.
J Postgrad Med. 2004 Oct-Dec;50(4):253-6; discussion 256.
Use of live non-human primates (NHPs) in biomedical research is a controversial issue in many parts of the world. Recent use of NHPs in research in Asian countries was surveyed.
To elucidate the use of NHPs in research in Asian countries.
The peer-reviewed literature was sampled according to the species used, area of research, research class and geographic location. Articles derived from database searches were scrutinised.
Studies were identified from the PrimateLit database.
Results suggested that NHP research was conducted in 16 countries, of which Japan accounted for two-thirds. About 55% of studies involved use of live animals, whereas the remaining 45% used some lower level of biological material. More than 70% of the studies using live NHPs included use of Old World monkeys. M. fuscata (18%), M. mulatta (17%) and M. fascicularis (10%) were the three most commonly used species. The most common research areas were neuroscience (44%), conservation (14%) and behaviour (11%). Due to high demand for NHPs, there is room for increased breeding of NHPs to be used for research in Asian countries.
在世界许多地区,在生物医学研究中使用活体非人类灵长类动物(NHPs)是一个有争议的问题。对亚洲国家近期在研究中使用NHPs的情况进行了调查。
阐明亚洲国家在研究中使用NHPs的情况。
根据所使用的物种、研究领域、研究类别和地理位置对同行评审文献进行抽样。对数据库搜索得出的文章进行了审查。
从灵长类文献数据库中识别研究。
结果表明,在16个国家进行了NHP研究,其中日本占三分之二。约55%的研究涉及使用活体动物,而其余45%使用了某种较低水平的生物材料。超过70%使用活体NHPs的研究包括使用旧世界猴。日本猕猴(18%)、恒河猴(17%)和食蟹猴(10%)是最常用的三个物种。最常见的研究领域是神经科学(44%)、保护(14%)和行为(11%)。由于对NHPs的需求很高,亚洲国家增加用于研究的NHPs繁殖量仍有空间。