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新世界灵长类动物在生物医学研究中的应用:过去四十年的概述。

The use of new world primates for biomedical research: an overview of the last four decades.

机构信息

Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Leal Prado, Vila Clementino, São Paulo (SP), Brazil.

出版信息

Am J Primatol. 2010 Dec;72(12):1055-61. doi: 10.1002/ajp.20864.

Abstract

Animal experimentation contributes significantly to the progression of science. Nonhuman primates play a particularly important role in biomedical research not only because of their anatomical, physiological, biochemical, and behavioral similarities with humans but also because of their close phylogenetic affinities. In order to investigate the use of New World primates (NWP) in biomedical research over the last four decades (1966-2005), we performed a quantitative study of the literature listed in bibliographic databases from the Health Sciences. The survey was performed for each genus of NWP that has been bred in the National Center of Primates in Brazil. The number of articles published was determined for each genus and sorted according to the country from which the studies originated and the general scientific field. The data obtained suggests that Brazil is a leader in generating knowledge with NWP models for translational medicine.

摘要

动物实验对科学的发展做出了重大贡献。非人类灵长类动物在生物医学研究中扮演着特别重要的角色,这不仅是因为它们在解剖学、生理学、生物化学和行为方面与人类相似,还因为它们在进化上与人类密切相关。为了研究过去四十年(1966-2005 年)中新世界灵长类动物(NWP)在生物医学研究中的应用,我们对健康科学领域文献数据库中列出的文献进行了定量研究。调查针对在巴西国家灵长类动物中心繁殖的每一种 NWP 属进行。为每个属确定了发表的文章数量,并根据研究来源国和一般科学领域进行了排序。获得的数据表明,巴西在利用 NWP 模型进行转化医学方面处于领先地位。

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