Schmid-Schönbein Geert W
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA.
Lymphat Res Biol. 2003;1(1):25-9; discussion 29-31. doi: 10.1089/15396850360495664.
The mechanism for interstitial fluid uptake into the lymphatics of the microcirculation remains speculative and uncertain. There exists a system of intralymphatic valves that prevent reflow along the length of the lymphatic channels, but these valves are insufficient to provide unidirectional flow at the level of the initial lymphatics. We propose that initial lymphatics have a two-valve system: a (primary) valve system at the level of the endothelium in addition to the classical (secondary) intralymphatic valves. The primary valves, in conjunction with the secondary valves, provide a mechanism that facilitates the unidirectional flow during periodic compression and expansion of initial lymphatics.
间质液进入微循环淋巴管的机制仍具有推测性且不确定。存在一个淋巴管内瓣膜系统，可防止淋巴液沿淋巴管长度逆流，但这些瓣膜不足以在初始淋巴管水平提供单向流动。我们提出，初始淋巴管有一个双瓣膜系统：除了经典的（二级）淋巴管内瓣膜外，在内皮水平还有一个（一级）瓣膜系统。一级瓣膜与二级瓣膜共同提供了一种机制，在初始淋巴管周期性压缩和扩张期间促进单向流动。
