Sampath G, Parikh S, Sangram P, Briggs D J
Institute of Preventive Medicine, Narayanaguda, Hyderabad 500 029, India.
Vaccine. 2005 Jan 19;23(9):1102-5. doi: 10.1016/j.vaccine.2004.08.036.
Over half of the world's malnourished children live in Asia where more than 90% of reported human rabies deaths occur. In order to determine the effect of malnutrition on the immune response to rabies post-exposure prophylaxis (PEP), 45 children with moderate to severe protein energy malnutrition (PEM) who were exposed to potentially rabid animals were enrolled in a clinical trial. Patients received purified chick embryo cell rabies vaccine (PCECV) on days 0, 3, 7, 14 and 30. Blood was drawn on days 0, 14 and 30 and evaluated for the presence of rabies virus neutralizing antibody. All children that met the protocol criteria developed rabies virus neutralizing antibody titers above the acceptable level of 0.5 IU/mL by day 14 and no serious adverse events were reported. We conclude that children in this study that received four or five doses of rabies vaccine intramuscularly developed an acceptable immune response despite their severe degree of protein energy malnutrition.
全球半数以上营养不良的儿童生活在亚洲，而据报告，90%以上的人类狂犬病死亡病例也发生在亚洲。为了确定营养不良对暴露后预防（PEP）狂犬病免疫反应的影响，45名暴露于潜在狂犬病动物的中度至重度蛋白质能量营养不良（PEM）儿童被纳入一项临床试验。患者在第0、3、7、14和30天接受纯化鸡胚细胞狂犬病疫苗（PCECV）。在第0、14和30天采集血液，评估狂犬病病毒中和抗体的存在情况。所有符合方案标准的儿童在第14天时狂犬病病毒中和抗体滴度均高于可接受水平0.5 IU/mL，且未报告严重不良事件。我们得出结论，本研究中接受四剂或五剂狂犬病疫苗肌肉注射的儿童，尽管蛋白质能量营养不良程度严重，但仍产生了可接受的免疫反应。
