Wilson M B, Adams D B, Garen P D, Gansler T S
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston.
Cancer. 1992 May 1;69(9):2235-43. doi: 10.1002/1097-0142(19920501)69:9<2235::aid-cncr2820690905>3.0.co;2-p.
Solid and papillary epithelial neoplasm of the pancreas (SPENP) is a rare lesion characteristically occurring in young women. By contrast with pancreatic ductal adenocarcinomas, SPENP is a slow-growing tumor that rarely metastasizes or is fatal. The current report describes light and electron microscopic and histochemical findings with DNA flow cytometric analyses of two cases of SPENP. The first patient was a 24-year-old woman; the second, a 72-year-old man. Although SPENP is rare in older men, both patients had characteristic radiographic and light microscopic features of SPENP. Ultrastructural evidence of acinar differentiation was seen in the first patient; the second patient had focal neuroendocrine differentiation. Flow cytometric analysis of the first tumor demonstrated diploid-range DNA content with a 5.8% S-phase fraction (SPF). The DNA cytometric analysis of a biopsy specimen from the second tumor revealed diploid-range DNA content with a 6.1% SPF, although subsequent sampling of the resected tumor showed an aneuploid population with a DNA index of 1.8 and SPF of 2.1%.
胰腺实性假乳头瘤（SPENP）是一种罕见的病变，特征性地发生于年轻女性。与胰腺导管腺癌不同，SPENP是一种生长缓慢的肿瘤，很少发生转移或导致死亡。本报告描述了两例SPENP的光镜、电镜、组织化学结果以及DNA流式细胞术分析。首例患者为一名24岁女性；第二例为一名72岁男性。尽管SPENP在老年男性中罕见，但两名患者均具有SPENP特征性的影像学和光镜表现。首例患者可见腺泡分化的超微结构证据；第二例患者有局灶性神经内分泌分化。对首例肿瘤的流式细胞术分析显示DNA含量处于二倍体范围，S期分数（SPF）为5.8%。对第二例肿瘤活检标本的DNA细胞术分析显示DNA含量处于二倍体范围，SPF为6.1%，尽管随后对切除肿瘤的采样显示为非整倍体群体，DNA指数为1.8，SPF为2.1%。
