Greenberg M L, Rennie Y, Grierson J M, Quin J W, Boadle R A
Department of Cytology, Westmead Hospital, Sydney, New South Wales, Australia.
Diagn Cytopathol. 1993 Oct;9(5):541-6. doi: 10.1002/dc.2840090514.
An intraoperative cytological diagnosis of a rare solid and papillary epithelial tumor of the pancreas was made at laparotomy in a 15-year-old Indian female. The characteristic cytological features were the presence of numerous large branching papillary clusters with central vascular stalks lined by multiple layers of uniform bland cells. Perivascular metachromatic material was prominent on Romanovsky stain. Ultrastructural identification of endocrine and exocrine features supports a multipotential cell origin in small pancreatic ductules. DNA analysis, not previously reported for this tumour, demonstrated a diploid population of tumour cells with a low S-phase fraction (0.4%). This would explain the bland nuclear morphology and favourable prognosis with a high rate of surgical cure for this neoplasm.
一名15岁印度女性在剖腹手术中经术中细胞学诊断为罕见的胰腺实性假乳头状上皮肿瘤。特征性细胞学表现为存在大量带有中央血管蒂的大分支乳头簇，其被多层形态一致的温和细胞所覆盖。血管周围异染性物质在罗曼诺夫斯基染色上很明显。内分泌和外分泌特征的超微结构鉴定支持其起源于小胰管的多潜能细胞。此前该肿瘤未报道过DNA分析情况，此次分析显示肿瘤细胞为二倍体群体，S期比例较低（0.4%）。这可以解释该肿瘤细胞核形态温和以及手术治愈率高、预后良好的情况。
