与肺炎支原体毒力特异性蛋白B和C缺失相关的突变的鉴定与互补
Identification and complementation of a mutation associated with loss of Mycoplasma pneumoniae virulence-specific proteins B and C.
作者信息
Waldo Robert H, Jordan Jarrat L, Krause Duncan C
机构信息
Department of Microbiology, 523 Biological Sciences Bldg., University of Georgia, Athens, GA 30602, USA.
出版信息
J Bacteriol. 2005 Jan;187(2):747-51. doi: 10.1128/JB.187.2.747-751.2005.
Abstract
A mutation in gene MPN142 (orf6) was identified in the Mycoplasma pneumoniae cytadherence mutant III-4. MPN142 encodes virulence-specific proteins P90 and P40 (proteins B and C, respectively). Analysis of MPN142 in a cytadhering revertant and complementation using a recombinant wild-type allele confirmed the role of this mutation in the cytadherence defect.
摘要
在肺炎支原体细胞黏附突变体III - 4中鉴定出基因MPN142（orf6）的一个突变。MPN142编码毒力特异性蛋白P90和P40（分别为蛋白B和蛋白C）。对细胞黏附回复突变体中的MPN142进行分析，并使用重组野生型等位基因进行互补实验，证实了该突变在细胞黏附缺陷中的作用。
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