Thompson Jill M, Gallagher Peter, Hughes John H, Watson Stuart, Gray John M, Ferrier I Nicol, Young Allan H
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
Br J Psychiatry. 2005 Jan;186:32-40. doi: 10.1192/bjp.186.1.32.
Persistent impairments in neurocognitive function have been described in patients with bipolar disorder whose disease is in remission. However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies.
To assess neurocognitive functioning in prospectively verified euthymic patients with bipolar disorder.
Sixty-three patients with bipolar disorder and a matched control group completed a comprehensive neurocognitive test battery. Euthymia was confirmed in the patient group by prospective clinical ratings over 1 month prior to testing. Saliva samples were collected to profile basal cortisol secretion.
Patients were significantly impaired across a broad range of cognitive domains. Across the domains tested, clinically significant impairment was observed in 3% to 42% of patients. Deficits were not causally associated with residual mood symptoms or hypercortisolaemia.
Neurocognitive impairment persists in patients whose bipolar disorder is in remission. This may represent a trait abnormality and be a marker of underlying neurobiological dysfunction.
双相情感障碍病情缓解的患者存在神经认知功能的持续损害。然而，诸如残留情绪症状和高皮质醇血症等方法学问题可能会混淆此类研究。
评估经前瞻性验证的双相情感障碍心境正常患者的神经认知功能。
63例双相情感障碍患者和一个匹配的对照组完成了一套全面的神经认知测试。在测试前1个月通过前瞻性临床评定确认患者组心境正常。收集唾液样本以分析基础皮质醇分泌情况。
患者在广泛的认知领域存在显著损害。在所测试的领域中，3%至42%的患者存在具有临床意义的损害。认知缺陷与残留情绪症状或高皮质醇血症无因果关系。
双相情感障碍病情缓解的患者存在神经认知损害。这可能代表一种特质异常，是潜在神经生物学功能障碍的一个标志。
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