血小板衍生生长因子CC通过对内皮细胞及其祖细胞的作用实现缺血组织的血管再生。
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
作者信息
Li Xuri, Tjwa Marc, Moons Lieve, Fons Pierre, Noel Agnes, Ny Annelii, Zhou Jian Min, Lennartsson Johan, Li Hong, Luttun Aernout, Pontén Annica, Devy Laetitia, Bouché Ann, Oh Hideyasu, Manderveld Ann, Blacher Silvia, Communi David, Savi Pierre, Bono Françoise, Dewerchin Mieke, Foidart Jean-Michel, Autiero Monica, Herbert Jean-Marc, Collen D, Heldin Carl-Henrik, Eriksson Ulf, Carmeliet Peter
机构信息
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium.
出版信息
J Clin Invest. 2005 Jan;115(1):118-27. doi: 10.1172/JCI19189.
Abstract
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
摘要
血小板衍生生长因子CC（PDGF-CC）是血管内皮生长因子（VEGF）/血小板衍生生长因子（PDGF）超家族中最近发现的成员，其血管生成机制和治疗潜力尚未完全明确。在此我们报告，PDGF-CC在缺血条件下可动员内皮祖细胞；诱导骨髓细胞分化为内皮细胞；并刺激内皮细胞迁移。此外，PDGF-CC在血管新生过程中诱导骨髓细胞分化为平滑肌细胞并刺激其生长。而且，给予PDGF-CC可增强心脏和肢体缺血后的血管再生。调节PDGF-CC的活性可能为治疗缺血性疾病提供新的机会。
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