Liu Dong, Song Meixuan, Jing Fengchuan, Liu Bin, Yi Qijian
Department of Cardiovascular Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Department of Pediatrics, Sichuan Clinical Research Center for Birth Defects, The Affliated Hospital of Southwest Medical University, Luzhou, China.
Front Genet. 2021 Dec 10;12:763496. doi: 10.3389/fgene.2021.763496. eCollection 2021.
Kawasaki disease (KD) is a systemic vasculitis that predominantly damages medium- and small-sized vessels, and mainly causes coronary artery lesions (CALs). The diagnostic criterion of KD mainly depends on clinical features, so children could be easily misdiagnosed and could suffer from CALs. Through analysis, a total of 14 immune-related DEGs were obtained, of which , , , and were identified as diagnostic markers of KD. Compared with the non-KD group, KD patients contained a higher proportion of naive B cells, activated memory CD4 T cells, gamma delta T cells, and neutrophils, while the proportions of memory B cells, CD8 T cells, activated memory CD4 T cells, and activated NK cells were relatively lower. In conclusion, immune-related genes can be used as diagnostic markers of KD, and the difference in immune cells between KD and non-KD might provide new insight into understanding the pathogenesis of KD.
川崎病（KD）是一种主要损害中小血管的系统性血管炎，主要导致冠状动脉病变（CALs）。KD的诊断标准主要取决于临床特征，因此儿童容易被误诊，并可能患有CALs。通过分析，共获得14个免疫相关差异表达基因（DEGs），其中，，，和被确定为KD的诊断标志物。与非KD组相比，KD患者的初始B细胞、活化记忆CD4 T细胞、γδ T细胞和中性粒细胞比例较高，而记忆B细胞、CD8 T细胞、活化记忆CD4 T细胞和活化NK细胞的比例相对较低。总之，免疫相关基因可作为KD的诊断标志物，KD与非KD之间免疫细胞的差异可能为理解KD的发病机制提供新的见解。
